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发布时间:2018-03-20 09:46:26  本文被阅次数: 我要打印 字号:

董伟杰

承担的国家级及省部级项目:(近5年)
1.国家自然科学基金(面上项目),Alpha-2,3-唾液酸转移酶-4(ST3GAL4)在非小细胞肺癌吉非替尼耐药中的作用及机制研究,2022/01-2025/12。
2.国家自然科学基金(面上项目),核心岩藻糖基转移酶对糖蛋白α2,6唾液酸化修饰的调节作用及其机理研究,2018/01-2019/12。
3.辽宁省教育厅科学研究项目,2020/09-2021/08。
4.中国科学院受体结构与功能重点实验室2020年度开放课题项目,胰腺癌肿瘤标志物的探究。
5.辽宁省自然科学基金,2015020273,粘蛋白及其糖链在乳腺癌发生发展中的变化规律研究,201507-201706。
6.教育部留学回国人员科研启动基金,粘蛋白在乳腺癌患者血清中糖链变化的研究。
获得专利:
1. 董伟杰,孙赫彬,徐晶,黄郭凌,李志,刘钢,提高检测灵敏度的蛋白质免疫印迹法,2020-02-18授权,中国,ZL201711194001.4.
2. 董伟杰,李雨晴,刘钢,刘冬琪,李志,以PVDF膜为载体准确提取糖链的方法,2021-08-02授权,中国,202010164080.X.
3. 龟山昭彦(Akihiko Kameyama),董伟杰,松野裕树,糖蛋白及多糖的检出方法 2015-05-29授权,日本,2012-012822.

代表性论文(近5年):
1. Comparison of the sensitivity of Western blotting between PVDF and NC membranes, Yufang Xiang#, Yuanyuan Zheng#, Shaobo Liu, Gang Liu, Zhi Li, Weijie Dong*,SCIENTIFIC REPORTS, 2021.
2. The importance of glycans of viral and host proteins in enveloped virus infection, Yuqing Li, Dongqi Liu, Yangting Wang, Wenquan Su, Gang Liu*, Weijie Dong*.  FRONTIERS IN IMMUNOLOGY, 2021.
3. Rapid glycosylation analysis of mouse serum glycoproteins separated by supported molecular matrix electrophoresis, Liu, Dongqi; Liu, Gang; Li, Yuqing; Wang, Yue; Zheng, Yuanyuan; Sha, Shanshan; Li, Wenzhe; Kameyama, Akihiko; Dong, Weijie*;JOURNAL OF PROTEOMICS, 2021.
4. Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice, Guoling Huang#; Zhi LI#; Yuqing Li#; Gang Liu; Shijie Sun; Jianguo Gu; Akihiko Kameyama; Wenzhe Li*; Weijie Dong*; Biochemical Journal, 2020, 477(6): 1179-1201.
5. High levels of fucosylation and sialylation of milk N-glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice; Zhou, Jiaorui#; Wang, Yue#; Fan, Qingjie; Liu, Yinhui; Liu, He; Yan, Jingyu; Li, Ming*; Dong, Weijie*; Li, Wenzhe*; The FASEB Journal, 2020, 34(3): 3715-3731.
6. A fixation method for the optimisation of western blotting; Xu Jing#; Sun Hebin#; Huang Guoling; Liu Gang; Li Zhi; Yang Hui; Jin Lingling; Cui Xiaolin; Shi Lei; Ma Tonghui; Kameyama Akihiko; Dong Weijie*; Scientific Reports, 2019, 9(1): 6649.
7. Wu, Yinshuang#; Chen, Xixi#; Dong, Weijie#; Xu, Zhongyang; Jian, Yuli; Xu, Chunyan; Zhang, Lin; Wei, Anwen; Yu, Xiao; Wang, Shidan; Wang, Yue; Liu, Gang; Sun, Xiaoxin; Wang, Shujing ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway, FRONTIERS IN ONCOLOGY, 2021.
8. Role of fucosyltransferase IV in the migration and invasion of human melanoma cells; Shan, Xiu#; Dong, Weijie#; Zhang, Li; Cai, Xin; Zhao, Yi; Chen, Qun; Yan, Qiu*; Liu, Jiwei*; IUBMB Life, 2020, 72(5): 942-956.
9. Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4; Xiaolu Ma#; Weijie Dong#; Zhen Su; Lifen Zhao; Yuan Miao; Nana Li; Huimin Zhou; Li Jia*; Cell Death & Disease, 2016, 7(7): 0-e2561.
10. α2,8-sialyltransferase is involved in the development of multidrug resistance viaPI3K/Akt pathway in human chronic myeloid leukemia; Xu Zhang#; Weijie Dong#; Huimin Zhou; Hongshuai Li; Ning Wang; Xiaoyan Miao; Li Jia*; IUBMB Life, 2015, 67(2): 77-87.
11. Identification of mucins by using a method involving a combination of on-membrane chemical deglycosylation and immunostaining; Yuki Matsuno; Weijie Dong; Seiya Yokoyama; Suguru Yonezawa; Hisashi Narimatsu; Akihiko Kameyama*; Journal of Immunological Methods, 2013, 394(1-2): 125-130.
12. Serum protein fractionation using supported molecular matrix electrophoresis; Weijie Dong; Yuki Matsuno,; Akihiko Kameyama*; Electrophoresis, 2013, 34(16): 2432-2439.
13. A procedure for Alcian blue staining of Mucins on Polyvinylidene Difluoride Membranes; Weijie Dong; Yuki Matsuno; Akihiko Kameyama*; Analytical Chemistry, 2012, 84(20): 8461-8466.

 

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