燕秋-大连医科大学基础医学院

燕秋,博士，教授，博士、硕士生导师。现任大连医科大学基础医学院生物化学与分子生物学教研室主任。从事分子生物学及糖复合物结构和功能的研究多年。现为辽宁省重点学科主任、辽宁省糖生物学与糖工程重点实验室主任。主持自然基金多项，获辽宁省科学进步奖两项。通过省级科技成果鉴定一项。被评为大连市优秀发明家, 辽宁省 “百千万人才工程” 千层次、辽宁省教学名师等荣誉称号。

学习经历：
1995.9—1998.7 理学博士大连医科大学/瑞典哥德堡大学
1987.9—1990.7 理学硕士白求恩医科大学
1981.9—1987.7 医学学士白求恩医科大学

工作经历：
1990.9—至今讲师、副教授、教授
硕士/博士生导师大连医科大学

研究方向：
糖生物学

主要学术任职：
全国医学生物化学与分子生物学专业理事、中国生殖生物学学会理事、辽宁省生物化学与分子生物学学会理事及中华医学会辽宁省分会理事等。

承担的国家级项目：（近5年）
1. 国家自然科学基金生殖内分泌激素对多囊卵巢综合征（PCOS）蛋白质糖基化的调控及致病机制的研究 2017.01-2020.12 主持
2. 国家自然科学基金胚胎发育和着床过程中O-岩藻糖化的特征及功能研究2013.01-2016.12 主持
3. 国家自然科学基金子宫内膜LeY/sLeX糖蛋白的分析及其在胚胎着床中作用的研究2011.01-2013.12 主持

代表性论文（近5年）：
1. Zheng Q, Zhang D, Yang YU, Cui X, Sun J, Liang C, Qin H, Yang X, Liu S, Yan Q. MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and α1,3-fucosylation. Cell Death Differ. 2017 Sep 15. IF:8.339
2. Yu M, Wang J, Liu S, Wang X, Yan Q. Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation. Sci Rep. 2017 Jul 13;7(1):5315.IF:4.259
3. Zhang S, Liu J, Ge B, Du M, Fu L, Fu Y, Yan Q. Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles. Drug Dev Ind Pharm. 2017 Oct;43(10):1734-1741.IF:2.295
4. Wang A, Lu C, Ning Z, Gao W, Xie Y, Zhang N, Liang J, Abbasi FS, Yan Q, Liu J. Tumor-associated macrophages promote Ezrin phosphorylation-mediated epithelial-mesenchymal transition in lung adenocarcinoma through FUT4/LeY up-regulation. Oncotarget. 2017 Apr 25;8(17):28247-28259.IF:5.168
5. Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats. Cell Death Dis. 2017 Oct 26;8(10):e3145.IF:5.965
6. Liu, Xue; Gao, Jiujiao; Sun, Yan; Zhang, Dandan; Liu, Tingjiao; Yan, Qiu; Yang, Xuesong. Mutation of N-linked glycosylation in EpCAM affected cell adhesion in breast cancer cells. BIOLOGICAL CHEMISTRY , 2017, OCT ; 398 ( 10 ): 1119 - 1126.IF:3.273
7. Zheng, Q.; Cui, X.; Zhang, D.; Yang, Y.; Yan, X.; Liu, M.; Niang, B.; Aziz, F.; Liu, S.; Yan, Q. Liu, J. miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and alpha 1,3-fucosylated glycans. Oncogenesis. 2017 Jul 10;6(7):e358.IF:4.143
8. Yang, Hong-Fang; Yu, Ming; Jin, Hui-Dan; Yao, Jia-Qi; Lu, Zhi-Li; Yabasin, Iddrisu B.; Yan, Qiu; Wen, Qing-Ping. Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating alpha 1, 6-Fucosylation via Wnt/beta-Catenin Signaling Pathway. FRONTIERS IN PHYSIOLOGY , 2017 Jul 26;8:510.IF:4.134
9. Gao, Wei; Liang, Jin-Xiao; Ma, Chi; Dong, Jing-yin; Yan, Qiu,.The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse. BIOMED RESEARCH INTERNATIONAL , 2017;2017:4176170.IF:2.476
10. Zhang, Dandan; Liu, Xue; Gao, Jiujiao; Sun, Yan; Liu, Tingjiao; Yan, Qiu; Yang, Xuesong. The role of epithelial cell adhesion molecule N-glycosylation on apoptosis in breast cancer cells. TUMOR BIOLOGY , 2017, MAR ; 39 ( 3 ):.IF:3.65
11. Aziz, Faisal; Gao, Wei; Yan, Qiu. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer. PATHOLOGY & ONCOLOGY RESEARCH . 2017, JAN ; 23 ( 1 ): 173 - 179.IF:1.736
12. Zheng, Qin; Dai, Kuixing; Cui, Xinyuan; Yu, Ming; Yang, Xuesong; Yan, Bin; Liu, Shuai; Yan, Qiu. Leukemia inhibitory factor promote trophoblast invasion via urokinase-type plasminogen activator receptor in preeclampsia. BIOMEDICINE & PHARMACOTHERAPY , 2016, MAY ; 80: 102 - 108.IF:2.759.
13. Tian L, Shen D, Li X, Shan X, Wang X, Yan Q, Liu J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4. Oncotarget. 2016 Jan 12;7(2):1619-32. IF:6.359.
14. Aziz F, Gao W, Yan Q. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer. Pathol Oncol Res. 2016 Oct 18.
15. Zheng Q, Dai K, Cui X, Yu M, Yang X, Yan B, Liu S, Yan Q. Leukemia inhibitory factor promote trophoblast invasion via urokinase-type plasminogen activator receptor in preeclampsia. Biomed Pharmacother. 2016 May;80:102-8.
16. Tian L, Shen D, Li X, Shan X, Wang X, Yan Q, Liu J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.Oncotarget. 2016 Jan 12;7(2):1619-32.
17. Aziz F, Wang X, Liu J, Yan Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016 Mar;31:158-66.
18. Gao J, Liu X, Yang F, Liu T, Yan Q, Yang X. By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis.Oncotarget. 2015 Sep 29;6(29):27187-98.
19. Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.Int J Oncol. 2015 Aug;47(2):701-9.
20. Gao W, Liang JX, Liu S, Liu C, Liu XF, Wang XQ, Yan Q. Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. Int J Clin Exp Med. 2015 Mar 15;8(3):3401-10.
21. Gao W, Liang JX, Yan Q. Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study. J Assist Reprod Genet. 2015 Aug;32(8):1179-86
22. Aziz F, Yang X, Wen Q, Yan Q. A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues. Mol Med Rep. 2015 Aug;12(2):2939-44
23. Zhang YM, Zhang YY, Bulbul A, Shan X, Wang XQ, Yan Q. Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.FEBS Lett. 2015 May 8;589(11):1225-33.
24. Yan X, Lin Y, Liu S, Aziz F, Yan Q.Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer.Biomed Pharmacother. 2015 Mar;70:299-304.
25. Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW.Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.Int J Oncol. 2015 Apr;46(4):1667-76.
26. Hongyan L, Shaoming T, Qiu Y.Correlation between FUT4 expression and its promoter methylation in HaCaT cells.Yi Chuan. 2015 Jan;37(1):48-54.
27. Aziz F, Yang X, Wang X, Yan Q.Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.J Cancer Res Clin Oncol. 2015 Jul;141(7):1221-35
28. Shan X, Fu YS, Aziz F, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS One. 2014 Dec 18;9(12):e115401.
29. Liu S, Wang J, Qin HM, Yan XM, Yang XS, Liu C, Yan Q. LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface. Cell Death Dis. 2014 Aug 28;5:e1396.(IF:5.177)
30. Liu S, Yang X, Wang J, Wei J, Zhang D, Wang X, Yan Q. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int. 2012 May 1;36(5):469-74. (IF:1.64)
31. Liu S, Yang X, Liu Y, Wang X, Yan Q. sLeX/L-selectin mediates adhesion in vitro implantation model. Mol Cell Biochem. 2011 Apr;350(1-2):185-92. (IF:2.33)
32. Gao J, Yan Q, Liu S, Yang X.Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2.PLoS One. 2014 Jul 14;9(7):e102590. (IF:3.534)
33. Gao J, Yan Q, Wang J, Liu S, Yang X. Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells.J Cell Physiol. 2014 Sep 9. (IF:3.874)
34. Wang J, Liu S, Qin HM, Zhao Y, Wang XQ, Yan Q. Pregnancy-associated plasma protein A up-regulated by progesterone promotes adhesion and proliferation of trophoblastic cells. Int J Clin Exp Pathol. 2014 Mar 15;7(4):1427-37. (IF:1.783)
35. Yang X, Wang J, Liu S, Yan Q. HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells. J Cell Biochem. 2014 Jan;115(1):168-78. (IF:3.368)
36. Yang X, Liu S, Yan Q.Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells. Cell Death Dis. 2013 Jul 25;4:e735. (IF:5.177)

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