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发布时间：2018-05-05 19:40:20  本文被阅次数： 我要打印 字号：大 中 小

孙明忠

孙明忠，博士，教授，硕士/博士生导师,现任大连医科大学生物技术教研室教授，校学科建设处副处长。1999年毕业于中国科学院长春应用化学研究所，硕博连读，获得理学博士学位。2000.2- 2007.3，先后在法国科学院、美国爱因斯坦医学院、美国凯斯西保留地等大学进行科学研究工作。2007年获辽宁省“百千万人才工程”学者称号，2010.11-11.5，牛津大学访问学者。现为大连医学会生化专科分会委员、大连医学会医学工程专科分会委员、大连医科大学新一届校学术委员会委员。在国内外杂志上发表论文120多篇，其中国外文章80余篇。

学习经历

1994年9月-1999年12月，中国科学院长春应用化学研究所，无机化学，理学博士(硕博连读)，导师:倪嘉缵院士

1990年9月-1994年7月，聊城师范学院，化学系，化学教育，理学学士

工作经历

2007.3-至今,大连医科大学基础医学院，教授

2015.1-至今,大连医科大学学科建设处,副处长

2010.11-2011.5,英国牛津大学Ludwig癌症研究所,访问学者

2005.8-2007.3, 美国凯斯西保留地大学蛋白质组学和质谱中心,副研究员

2003.8-2005.7, 美国爱因斯坦医学院生理与生物物理系,副研究员

2002.10-2003.7,美国马萨诸塞大学医学院医药系,博士后

2001.3-2002.9, 美国克拉克大学生物化学与分子生物学系,副研究员

2000.2-2001.2, 法国科学院生物结构研究所,博士后

研究方向：

1.肿瘤淋巴道转移预警标志物筛选、临床相关性及作用机制；

2. 蛇毒蛋白生物活性及应用研究。

主要学术任职：

大连医科大学校学术委员会委员；大连市医学会生化专科分会委员；大连市医学会医学工程专科分会委员；中国生化与分子生物学会会员。

承担的国家级项目：（近5年）

1.国家自然科学基金(81672737), ceRNA调控miR-330-3p、Ereg在肿瘤淋巴道转移中的作用机制及临床相关性研究,53万元, 2017.1-2020.12,项目负责人

2.国家自然科学基金(81171957), Anxa3,Anxa5,Anxa11调控肿瘤细胞淋巴道转移力/预警肿瘤转移及其共相关蛋白研究,55万元，2012.1-2015.12，项目负责人

代表性论文（近5年）：

  1. Chunmei Guo, Dongting Zhao, Qiuling Zhang, Shuqing Liu, Ming-Zhong Sun. miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinomaviainhibiting Raf/MEK/ ERK pathway and epithelialmesenchymal transition. Scientific Reports, 2018, 8: 2375(通讯作者).

  2. Xujuan Sun, Bin Wei, Shuqing Liu, Chunmei Guo, Na Wu, Qinlong Liu, Ming-Zhong Sun. Anxa5 mediates in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentiallyviaERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin. Biomedicine & Pharmacotherapy,2016 , 84: 645-54(通讯作者).

  3. Shuqing Liu, Chunmei Guo, Jiasheng Wang, Bo Wang, Houbao Qi, Ming-Zhong Sun. ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun. Oncotarget, 2016,7(13):16297-310(通讯作者).

  4. Boya Peng, Shuqing Liu, Chunmei Guo,Xujuan Sun, Ming-Zhong Sun. ANXA5 level is linked toin vitroandin vivotumor malignancy and lymphatic metastasis of murine hepatocarcinoma cell. Future Oncology.2015, 12(1): 31-42(通讯作者).

  5. Chunmei Guo, Shuqing Liu, Panpan Dong, Dongting Zhao, Chengyi Wang, Zhiwei Tao,Ming-Zhong Sun. Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2viaTGF-β signal pathway. Scientific Reports. 2015, 5:18215. (通讯作者).

  6. Houbao Qi, Shuqing Liu, Chunmei Guo, Jiasheng Wang, Frederick T Greenaway, Ming- Zhong Sun. Role of AnxA6 in cancers. Oncology Letters, 2015, 10: 1947-52(通讯作者).

  7. Ming-Zhong Sun, Yanhua Cui, Chunmei Guo, Baochang Zhao, Shuqing Liu. rAdinbitor, a disintegrin fromAgkistrodon halys brevicaudus stejneger, inhibits tumorigenicity of hepatocarcinomaviaenhanced anti-angiogenesis and immunocompetence. Biochimie, 2015, 116: 34-52(第一作者) .

  8. Bin Wei, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Annexin A4 and cancer. Clin Chim Acta, 2015, 447: 72-8(通讯作者).

  9. Ji Shi, Longlong Meng, Ming-Zhong Sun, Chunmei Guo , Xujuan Sun, Qiuyue Lin, Shuqing Liu.CRKL knockdown promotesin vitroproliferation, migration and invasion,in vivotumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells. Biomedicine & Pharmacotherapy 2015, 71: 84-90(通讯作者).

  10. Shuqing Liu, Jiasheng Wang, Chunmei Guo, Houbao Qi, Ming-Zhong Sun. Annexin A11 knockdown inhibitsin vitroproliferation and enhances survival of Hca-F cellviaAkt2/FoxO1 pathway and MMP-9 expression. Biomedicine & Pharmacotherapy,2015,70:58-63(通讯作者).

  11. Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. The role of CT10 regulation of kinase-like in cancer. CRKL in cancer. Future Oncology, 2014, 10(16): 2687-97(通讯作者).

  12. Shuqing Liu, Chunmei Guo , Yimeng Guo,, Hongshan Yu, Frederick Greenaway, Ming-Zhong Sun. Comparative binding affinities of flavonoid phytochemicals with bovine serum albumin. Iranian Journal of Pharmaceutical Research, 2014, 13(3): 1019-28(通讯作者).

  13. Jiasheng Wang, Chunmei Guo, Shuqing Liu, Houbao Qi, Yuling Yin, Rui Liang, Ming-Zhong Sun, Frederick Greenaway. Annexin A11 in disease. Clin Chim Acta,2014,431:164-8(通讯作者).

  14. Boya Peng, Chunmei Guo, Hongwei Guan, Shuqing Liu, Ming-Zhong Sun. Annexin A5 as a potential marker in tumors. Clin Chim Acta, 2014, 427:42-8(通讯作者).

  15. Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Potential role of Anxa1 in cancer. Future Oncology, 2013, 9(11): 1773-93(通讯作者).

  16. Chunmei Guo, Shuqing Liu, Frederick Greenaway, Ming-Zhong Sun. Potential role of annexin A7 in cancers. Clin Chim Acta, 2013, 423: 83-9(通讯作者).

  17. Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Sequence and bioinformatic characterization of ESTs originated fromGloydius shedaoensis shedaoensisvenom gland. The Anatomical Record, 2013, 296: 807-14(通讯作者).

  18. Chunmei Guo, Shuqing Liu, Ming-Zhong Sun. Novel insight into the role of GAPDH playing in tumor. Clinical and Translational Oncology, 2013, 15(3): 167-72(通讯作者).

  19. Na Wu, Shuqing Liu, Chunmei Guo, Zhijie Hou, Ming-Zhong Sun. The role of Annexin A3 playing in cancers. Clinical and Translational Oncology, 2013,15(2):106-10(通讯作者).

  20. Chunmei Guo, Shuqing Liu, Jiasheng Wang, Ming-Zhong Sun. ACTB in cancer. Clin Chim Acta, 2013, 417: 39-44(通讯作者).

  21. Xiaohui Zhang, Shuqing Liu, Chunmei Guo, Junwei Zong, Ming-Zhong Sun. The association of annexin A2 and cancers.Clinical and Translational Oncology,2012,14(9):634-40(通讯作者).

  22. Shuqing Liu, Chunmei Guo, Dachang Wu, Yixin Ren, Ming-Zhong Sun, Peng Xu. Protein indicators for HaCaT cell damage induced by UVB irradiation. J Photochem Photobiol B, 2012,114: 94-101(通讯作者).

  23. Ming-Zhong Sun, Zhuzhu Guan, Shuqing Liu, Xin Zhou, Na Wang, Shujuan Shao, Dongmei Lin. Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor. Biomedicine & Pharmacotherapy, 2012,66(4): 242-8(第一作者).

  24. Chunmei Guo, Shuqing Liu, Yiwen Yao, Qiaoqiao Zhang, Ming-Zhong Sun. Past decade study of snake venom L-amino acid oxidase. Toxicon, 2012,60(3):302-11(通讯作者).

  25. Junwei Zong, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun, Jianwu Tang. Proteomic research progress in lymphatic metastases of cancers. Clinical and Translational Oncology,2012, 14(1):21-30(通讯作者).

  26. Ming-Zhong Sun, Xiaoying Zhang, Yi Xin. Purification and characterization of an endo-D-arabinase produced by Cellulomonas. The Protein Journal, 2012,31(1):51-8(第一作者).

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