茅卫锋-大连医科大学基础医学院

教育经历:

2004-2009 博士美国密西根州立大学Michigan State University, Michigan 遗传学Genetics

2000-2003 硕士中国科学院 遗传学 Genetics

1996-2000 本科厦门大学生命科学学院 生物技术 Biotechnology

工作经历:

2020-迄今教授,大连医科大学基础医学院生物制药教研室

2012-2020 副教授,大连医科大学基础医学院生物制药教研室

研究方向为遗传学和生物信息学。主持国家自然科学基金2项，省自然基金2项，获辽宁省杰出青年学者支持计划和辽宁省“百千万人才工程”千人层次支持。指导硕士研究生发表SCI论文20余篇，指导5名硕士研究生获得国家奖学金，硕士毕业生在知名大学继续攻读博士学位和在生物制药企业工作。

通讯作者发表SCI文章：

1. Ma C, Qin Y, Wang Y, Zhu C, Gao X, Zhang P, Gu Y, Zhang S, Lin J, Wang J, Mao W*，Targeting DNA-PKcs promotes anti-tumoral immunity via triggering cytosolic DNA sensing and inducing an inflamed tumor immuno-microenvironment in metastatic triple negative breast cancer. Genes & Diseases, 2023.（IF=6.9）

2. Lin, J., T. Song, C. Li, Mao W*, GSK-3beta in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer. Biochim Biophys Acta Mol Cell Res, 2020. 1867(5): p. 118659.（IF=5.01）

3. Gao X, Yang Y, Wang J, Zhang L, Sun C, Wang Y, Zhang J, Dong H, Zhang H, Gao C, Zhang B, Feng B, Mao W*, Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation. Biomed Pharmacother 2020, 129: 110460 (IF=6.529).

4. Gao X, Wang J, Li M, Wang J, Lv J, Zhang L, Sun C, Ji J, Yang W, Zhao Z, Mao W*. Berberine attenuates XRCC1‐mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs. J Cell Mol Med. 2019, 23(10):6797-6804. (IF=4.486).

5. Qin Y^†, Mao W^†, Pan L, Sun Y, Fan F, Zhao Y, Cui Y, Wei X, Kohama K, Li F, Gao Y. Inhibitory effect of recombinant human CXCL8(3-72)K11R/G31P on atherosclerotic plaques in a mouse model of atherosclerosis. Immunopharmacology and Immunotoxicology. 2019. 41(3):1-9. (IF=2.352).

6. Zhang Z, Sun C, Zhang L, Chi X, Ji J, Gao X, Wang Y, Zhao Z, Liu L, Cao X, Yang Y, Mao W*. Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin. Biomed Pharmacother. 2019 Jan;109:1541-1546. (IF=4.545).

7. Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, Lv J, Sun S, Zhang C, Mao W*. Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomed Pharmacother. 2018 Jan;97:115-119 (IF=3.743).

8. Zhao Q, Guan J, Zhang Z, Lv J, Wang Y, Liu L, Zhou Q, Mao W*. Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib. Biomedicine & Pharmacotherapy. 2017, 94: 165-168 (IF=3.457).

9. Zhao Y, Jing Z, Lv J, Zhang Z, Lin J, Cao X, Zhao Z, Liu P*, Mao W*, Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo. Biomedicine & Pharmacotherapy. 2017, 95:18-24 (IF=3.457).

10. Guan J, Zhao Q, Lv J, Zhang Z, Sun S and Mao W*, Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors. Oncology letters, 2017, 4965-4970 (IF=1.39).

11. Guan J, Zhao Q, Mao W*. Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation. BBA-Molecular Cell Research. 2016, 1863(12) :3106-3115 (IF=4.521).

12. Zhao Y, Jing Z, Li Y, Mao W*. Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis. Oncol Rep. 2016, 36(1):567-72 (IF=2.4).

13. Yan W, Li F, Qin Y, Ren Y, Zheng L, Dai X, Mao W*, Cui Y. Evaluation of recombinant CXCL8(3-73)K11R/G31P in muscle fibrosis and Trichinella larvae encapsulation in a murine model of trichinellosis. Int Immunopharmacol. 2016, 35:323-6 (IF=2.956).

主持自然基金和人才项目

1. 中国自然科学基金委面上基金， DNA双链断裂选择性末端连接修复的基础研究。

2. 中国自然科学基金委青年基金，XRCC1在B细胞淋巴瘤IgH基因DNA损伤修复作用的研究。

3. 辽宁省自然科学基金重点计划项目，微同源介导的 DNA 末端连接修复在肿瘤放疗耐药中作用的研究。

4. 大连医科大学英才计划

5. 辽宁省杰出青年学者支持计划。

6. 辽宁省“百千万人才工程”千人层次。