【个人简介】
魏晶，医学博士，大连医科大学基础医学院教授，硕士生导师。
2014年10月获大连医科大学博士学位。博士期间，主要从事细胞因子、趋化因子在细菌性肺炎的作用的研究。
博士毕业后，主要从事类风湿关节炎、骨性关节炎发病机制相关研究。主持辽宁省科技厅科学基金1项，辽宁省教育厅科学基金2项。作为项目主要执行人，参与多项国家自然科学基金面上项目。发表多篇SCI文章。
【研究方向】
类风湿关节炎发病机制的研究
【承担项目】
1. 辽宁省教育厅高校基本科研项目：mid49/51诱发的线粒体动力学失衡调控RASF侵袭性表型的机制及靶向干预研究（LJ212410161038）；2024/09-2026/08，5万元。
2. 辽宁省科技厅自然基金项目：瘦素促进滑膜成纤维细胞脂肪酸β氧化在RA滑膜增生中的作用研究（20180550789）；2018/09-2020/08；5万元。
3. 辽宁省教育厅高校基本科研项目：瘦素对类风湿关节炎滑膜成纤维细胞迁移、促血管生成的影响（LQ2017007）；2017/01-2020/08；5万元。
【代表性文章】
(1)Zhen Wang, Guolin Zhang, Jixian Fu, Guangxing Li, Zhihao Zhao, HyokChol Choe, Kaiyue Ding, Junnan Ma, Jing Wei, Dong Shang, Lin Zhang. Mechanism exploration and biomarker identification of glycemic deterioration in patients with diseases of the exocrine pancreas.Sci Rep, 2024 Feb 22;14(1):4374.
(2)Wei J, Huang X, Zhang X, Chen G, Zhang C, Zhou X, Qi J, Zhang Y, Li X. Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway. Cell Death Dis. 2023 Feb 9;14(2):97.
(3)Ye X, Yin C, Huang X, Huang Y, Ding L, Jin M, Wang Z, Wei J, Li X. ROS/TGF-β signal mediated accumulation of SOX4 in OA-FLS promotes cell senescence. Exp Gerontol. 2021 Dec;156:111616.
(4)Zhen Wang, Xinxin Huang, Xiaokang Ye, Xia Li, Jing Wei. Roles of leptin on the key effector cells of rheumatoid arthritis. Immunol Lett. 2021 May:233:92-96.
(5)Yuan Q, Chen H, Li X*, Wei J. Leptin: an unappreciated key player in SLE. Clinical Rheumatology. 2020 Feb;39(2):305-317.
(6)Elkhider A, Wei J, Al-Azab M, Tang Y, Walana W, Li W, Yuan B, Ye Y, Zhang Y, Li X. IL-34 modulates rheumatoid synovial fibroblasts proliferation and migration via ERK/AKT signalling pathway. Clinical and Experimental Rheumatology. 2020;38(3):479-487.
(7)Wei J, Ouyang X, Tang Y, Li H, Wang B, Ye Y, Jin M, Al Azab M, Li W, Li X*. ER-stressed MSC displayed more effective immunomodulation in RA CD4+CXCR5+ICOS+follicular helper-like T cells through higher PGE2 binding with EP2/EP4. Modern Rheumatology. 2020 May;30(3):509-516.
(8)Al-Azab M, Wei J, Ouyang X, Elkhider A, Walana W, Sun X, Tang Y, Wang B, Li X*. TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis. European Cytokine Network. 2018 Mar 1;29(1):27-35. doi: 10.1684/ecn.2018.0405.
(9)Wang M, Wei J, Li H, Ouyang X, Sun X, Tang Y, Chen H, Wang B, Li X*. Leptin Upregulates Peripheral CD4+CXCR5+ICOS+ T Cells via Increased IL-6 in Rheumatoid Arthritis Patients. Journal of Interferon and Cytokine Research. 2018, 38 (2):86-92.
(10) Sun X, Wei J, Tang Y, Wang B, Zhang Y, Shi L, Guo J, Hu F, Li X*. Leptin-induced migration and angiogenesis in rheumatoid arthritis is mediated by reactive oxygen species. FEBS Open Bio. 2017, 7(12): 1899-1908.
【招生专业】
免疫学
【联系方式】
weijingdl@126.com
