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发布时间:2025-09-24 13:36:42  本文被阅次数: 我要打印 字号:

钟民涛

    钟民涛,教授,硕士生导师,医学博士。2005年7月工作于大连医科大学微生物教研室,担任医学微生物学的教学及科研工作。美国匹兹堡大学医学院访问学者。

2005年工作以来,主持国家自然科学基金1项、辽宁省教育厅科研项目1项和横向课题1项,参与了国家自然科学基金项目2项,目前以第一作者或通讯作者已发表论文40余篇,其中sci论文20余篇,

以第一完成人获得辽宁省科技进步三等奖1项,参与获得辽宁省科技进步二等奖1项,大连市科技进步2等奖1项,以主要完成人获得授权专利11项。


研究方向

抗肿瘤及耐药菌的中草药制剂及微生物制剂的研发。


承担项目

1. 2014.1-2016.12;项目名称及编号:具有RCC1和ANK结构域的香菇转录本表达蛋白Latcripin-4诱导肿瘤细胞凋亡的分子机制研究(国家自然科学基金;81301955)

2.2012.9-2015.9;项目名称及编号:桑螵蛸抗MRSA有效成分的分离鉴定及其抗菌的分子机制研究(辽宁省教育厅一般项目,L2012330)

3.2024.08-2027.08;桑螵蛸提取物的制备及其抑菌作用(横向课题,厦门市康明克斯科技有限公司)


代表性文章:

(1) Syed Riaz Ud Din; Sumbul Saeed; Shahid Ullah Khan; Fawad Mueen Arbi; Guo Xuefang; Mintao.Zhong ; Bacteria-driven cancer therapy: Exploring advancements and challenges, Critical Reviewsin Oncology/Hematology, 2023, 191: 104141(通讯作者)

(2) Xiaorong Guo; Lei Liu; Wenqi Zhao; Xingyun Li; Xiaoli Wang; Anhong Ning; Jing Cao; Wei Zhang; Liang Cao; Mintao Zhong ; The protective effect of Schisandra chinensis(Turcz.) Baill polysaccharide on DSS‐induced ulcerative colitis in mice via the modulation of gut microbiota and inhibition of NF‐κB activation, Journal of the Science of Food and Agriculture, 2023,8(通讯作者)

(3) Din, Syed Riaz Ud; Saeed, Sumbul; Khan, Shahid Ullah; Kiani, Faisal Ayub; Alsuhaibani, Amnah Mohammed; Zhong, Mintao.Bioactive Compounds (BACs): A Novel Approach to Treat and Prevent Cardiovascular Diseases.CURRENT PROBLEMS IN CARDIOLOGY , 2023, 48 ( 7 ): .(通讯作者)

(4) Saeed, Sumbul; Din, Syed Riaz Ud; Khan, Shahid Ullah; Gul, Rukhsana; Kiani, Faisal Ayub; Wahab, Abdul; Zhong, Mintao.Nanoparticle: A Promising Player in Nanomedicine and its Theranostic Applications for the Treatment of Cardiovascular Diseases.2023, 48 ( 5 ): . (通讯作者)

(5) Lun, Yong-Zhi; Qiu, Wei; Zhao, Wenqi; Lin, Hua; Zhong, Mintao; Sun, Jie.Characteristics of Intestinal Flora in Pregnant Women with Mild Thalassemia Revealed by Metagenomics. JUNDISHAPUR JOURNAL OF MICROBIOLOGY , 2021, 14 ( 10 ): (通讯作者)

(6) Anti-tumor effect of polysaccharide from Pleurotus ostreatus on H22 mouse Hepatoma ascites in-vivo and hepatocellular carcinoma in-vitro model,AMB EXPRESS , 2021.12; 11 ( 1 ):1-15(通讯作者)

(7) Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling,EUROPEAN JOURNAL OF PHARMACOLOGY , 2021.09, 15 ; 907 : 1-12(通讯作者)

(8) Polysaccharides isolated from Cordyceps Sinensis contribute to the progression of NASH by modifying the gut microbiota in mice fed a high-fat diet,PLOS ONE , 2020.07; 15 ( 6 ):1-20(通讯作者)

(9) Comparative study to develop a single method for retrieving wide class of recombinant proteins from classical inclusion bodies,APPLIED MICROBIOLOGY AND BIOTECHNOLOGY , 2018.03 ; 102 ( 5 ): 2363 - 2377(通讯作者)

(10) Latcripin-7A, derivative ofLentinulaedodesC(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1)phase in breast cancer cells,APPLIED MICROBIOLOGY AND BIOTECHNOLOGY , 2020.12; 104 ( 23 ): 10165 - 10179.(并列一作)

(11) Guo, Xuefang; Wang, Xiaoli; Liu, Min; Chen, Lei; Chanda, Warren; Pahiar, Arshad Ahmed; Li, Xingyun; Zhang, Wei; Ning, Anhong; Huang, Min; Cao, Jing; Zhong, Mintao.Expression and Antitumor Function of Latcripin-4 RCC1 and ANK Domain Protein on HepG2 from the Shiitake Medicinal Mushroom, Lentinus edodes C91-3 (Agaricomycetes), Transcriptome.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS , 2018, ; 20 ( 12 ): 1163 - 1172.(通讯作者)

(12) Wang, Wen-dong; Zhang, Nan-nan; Chanda, Warren; Liu, Min; Din, Syed Riaz Ud; Diao, Yun-peng; Liu, Lei; Cao, Jing; Wang, Xiao-li; Li, Xing-yun; Ning, An-hong; Huang, Min; Zhong, Min-tao.Antibacterial and anti-biofilm activity of the lipid extract from Mantidis ootheca on Pseudomonas aeruginosa.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B , 2018, MAY ; 19 ( 5 ): 364 - 371(通讯作者)

(13) Chanda, Warren; Joseph, Thomson P.; Guo, Xue-fang; Wang, Wen-dong; Liu, Min; Vuai, Miza S.; Padhiar, Arshad A.; Zhong, Min-tao.Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B , 2018, APR ; 19 ( 4 ): 253 - 262.(通讯作者)

(14) Song, Shiyu; Vuai, Miza S.; Zhong, Mintao.The role of bacteria in cancer therapy - enemies in the past, but allies at present.INFECTIOUS AGENTS AND CANCER , 2018, MAR ; 13 : (通讯作者).

(15) Chanda, Warren; Joseph, Thomson Patrick; Padhiar, Arshad Ahmed; Guo, Xuefang; Min, Liu; Wang, Wendong; Lolokote, Sainyugu; Ning, Anhong; Cao, Jing; Huang, Min; Zhong, Mintao.Combined effect of linolenic acid and tobramycin on Pseudomonas aeruginosa biofilm formation and quorum sensing. EXPERIMENTAL AND THERAPEUTIC MEDICINE , 2017, NOV ; 14 ( 5 ): 4328 - 4338.(通讯作者)

(16) Chanda, Warren; Joseph, Thomson P.; Wang, Wendong; Padhiar, Arshad A.; Zhong, Mintao.The potential management of oral candidiasis using anti-biofilm therapies.MEDICAL HYPOTHESES , 2017, SEP ; 106 ( ): 15 - 18.(通讯作者)

(17) Tian, Li; Wang, Xiaoli; Li, Xingyun; Liu, Ben; Zhang, Wei; Cao, Jing; Ning, Anhong; Huang, Min; Zhong, MintaoIn vitro antitumor activity of Latcripin-15 regulator of chromosome condensation 1 domain protein.ONCOLOGY LETTERS , 2016, NOV ; 12 ( 5 ): 3153 - 3160.(通讯作者).

(18) Mintao Zhong, Ben Liu, Xiaoli Wang, Lei Liu, Yongzhi Lun, Xingyun Li, Anhong Ning, Jing Cao, Min Huang.DenovocharacterizationofLentinulaedodesC(91-3) transcriptome by deep Solexa sequencing.Biochemical and Biophysical Research Communications 431 (2013):111–115(第一作者)

(19) MintaoZhong, Ben Liu, Yingli Liu, Xiaoli Wang, Xingyun Li, Lei Liu, AnhongNing,JingCao,Min Huang. The antitumor activities of Lentinus edodes C91-3 mycelia fermentation protein on S180 (mouse sarcoma cell) in vitro and in vivo. Journal of Medicinal Plant Research ,2012, 6(12):488-2492.(第一作者)

(20) Mintao Zhong, Min Huang*, Lei Liu, Xiaoli Wang, Xingyun Li, Anhong Ning and Jing Cao.The immune-response enveloped-virus treatment for H22 ascitic tumors in mice. African Journal of Microbiology Research.2011, 5(22):3771-3777.(第一作者)

(21) Dan-Yu Zhao, Chuan-Xun Li, Shan-shan Huang, Min-Tao Zhong(通讯作者)and Hou- Li Zhang. (E)-N′-(4-Bromo¬benzyl¬idene)-3,4-dihydroxy¬benzohydrazide monohydrate..ActaCrystallogr Sect E Struct Rep Online. 2009 October 1.

(22) Wang W, Chanda W, Zhong M(通讯作者).The relationship between biofilm and outer membrane vesicles: a novel therapy overview. FEMS Microbiol Lett 362,2015 ; 362 ( 15 ):


发明专利

(1) 桑螵蛸提取物、提取方法及在制备抑菌药物中的应用,专利号ZL201410220271.8(已授权);

(2) 具有抗肿瘤活性的香菇发酵干粉制剂及制备方法,专利号 ZL 2007101579 .0(已授权);

(3) 具有抗肿瘤活性的香菇发酵口服液及制备方法,专利号ZL 200710157911.5 (已授权);

(4) 专利号:201310410754.X 名称:香菇C91-3菌株的Latcripin-13基因片段、编码蛋白及制备方法(已授权)

(5) 专利号:201310411828.1 名称:香菇C91-3菌株的Latcripin-2基因片段、编码蛋白及制备方法(已授权)

(6) 专利号:201310411826.2 名称:香菇C91-3菌株的Latcripin-4基因片段、编码蛋白及制备方法(已授权)

(7) 专利号:201310410780.2 名称:香菇C91-3菌株的Latcripin-15基因片段、编码蛋白及制备方法(已授权)

(8) 专利号:201310337850.6 名称:从香菇C91-3菌株中提取抗氧化、抗肿瘤Latcripin-3基因片段的方法(已授权)

(9) 申请号:201310411845.5 名称:香菇C91-3菌株的Latcripin-5基因片段、编码蛋白及制备方法(已授权)

(10) 申请号:201310410779.X 名称:香菇C91-3菌株的Latcripin-16基因片段、编码蛋白及制备方法(已授权)

(11) 申请号:201310411810.1 名称:香菇C91-3菌株的Latcripin-18基因片段、编码蛋白及制备方法(已授权)


出版教材:

1.数字化《医学微生物学与寄生虫学》, 副主编, 人民卫生出版社, 2017

2.《幽门螺杆菌》视听教材光盘, 副主编, 人民卫生出版社, 2008

3.《医学微生物学实验学》第4版, 参编, 科学出版社, 2015

4.《医学微生物学与寄生虫学》第5版, 参编, 人民卫生出版社, 2022

5.《病原生物学与免疫学基础》第2版, 参编, 人民军医出版社, 2012

6.案例版《医学微生物学》第3版, 参编, 科学出版社, 2020

7.《医学微生物学与寄生虫学》第4版, 参编, 人民卫生出版社, 2017

8.《微生物学及微生物学检验》, 参编, 人民军医出版社, 2006


近期获奖情况

1. 中药香菇Lp 系列功能蛋白的表达及活性解析技术平台的建立应用.2023 年度辽宁省科技进步三等奖,第一完成人;证书编号:2023-J-3-101-R01

2.抗MRSA慢性创面感染的天然小分子化合物高通量筛选及应用, 辽宁省科技进步二等奖.排名5;证书编号:2015J-2-70-05


社会兼职

1.中国医药教育协会微生态与健康专业委员会第二届委员

2.辽宁省预防医学会微生态专业委员会第六届委员

3.辽宁省微生物学会第七届理事会理事


招生专业:病原生物学


联系方式

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