周慧敏博士,副教授
科研方向:糖基因与肿瘤分子生物学
近五年参与的课题:
1.国家重要基础研究发展计划项目(973计划),肿瘤的糖化学生物学前沿研究,分课题:糖链对肿瘤细胞生物学行为的影响及机制研究(2012CB822103),2012.1. -2016.12.
2.国家自然科学基金,糖基因在白血病多药耐药性中的特征性改变及其诊断价值(81271910),2013.1. -2016.12.,排名第2
3.国家自然科学基金,白血病耐药糖复合物标志物的筛选、鉴定及其功能研究(81472014),2015.1. -2018.12.,排名第2
4.辽宁省自然科学基金,糖链在白血病耐药性中的变化规律及其功能机制研究;(2014023043),2014.7. -2016.6.,排名第4
代表性文章:
1.Luo S, Chen Y, Zhao L, Qi X, Miao X,Zhou H(并列通讯作者), Jia L. Effect of nutritional supplement on bone marrow-derived mesenchymal stem cells from aplastic anemia. The British journal of nutrition 2018.
2.Yang G, Zhao L, Liu B, Shan Y, Li Y,Zhou H(并列通讯作者), Jia L.Nutritional support contributes to recuperation in a rat model of aplastic anemia by enhancing mitochondrial function.Nutrition2018, 46:67-77.
3.Zhou H, Li Y, Liu B, Shan Y, Li Y, Zhao L, Su Z, Jia L.Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression.Gene2017,626:106-118.
4.Cai H,Zhou H(并列第一作者), Miao Y, Li N, Zhao L, Jia L. MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.Laboratory Investigation 2017, 97(5):530-542.
5.Zhou H, Li Y, Song X, Zhao Y, Cheng L, Zhao L, Jia L. CHST11/13 Regulate the metastasis and chemosensitivity of human hepatocellular carcinoma cells via mitogen-activated protein kinase pathway.Digestive Diseases and Sciences 2016, 61(7):1972-1985.
6.Zhou H, Ma H, Wei W, Ji D, Song X, Sun J, Zhang J, Jia L.B4GALT family mediates the multidrug resistance ofhuman leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.Cell Death and Disease 2013, 4:e654.
科研获奖:
辽宁省科技进步二等奖,糖链在肿瘤耐药性中的变化规律及其功能,2015,排名4 (2015J-2-72-04)
参编教材:
1.实用细胞培养技术,人民卫生出版社,2012
2.医学微生物实验学,科学出版社,2015
3.微生物耐药的基础和临床,人民卫生出版社,2017