丁文勇,博士,副教授,硕士生导师。现工作于大连医科大学基础医学院生物化学与分子生物学教研室。发表国际期刊论文(SCI收录)11篇;主持国家自然科学基金项目1项;973子课题2项;联系方式:dingwy@dmu.edu.cn
学习经历:
2003-09至2009-08,中国科学院大连化学物理研究所,生物技术部,博士,导师:邹汉法
1992-09至1995-06,大连医科大学,生化教研室,硕士,导师:赵宝昌
1984-09至1989-06,吉林大学,分子生物学系,本科
工作经历:
1995-06至现在,大连医科大学,生化教研室,副教授
研究方向:
干细胞基因表达调控,帕金森病
承担的国家级项目:(近5年)
国家自然科学基金委员会, 面上项目, 81272429,Oct4 异构体在干细胞和肿瘤细胞中的表达调控和作用机制,2013-01至2016-12,70万,已结题,主持
科技部,国家重大科学研究计划,2011CB965000,三维培养干细胞自我更新与定向分化的调控网络,2011-01至2015-08,45万(子课题),已结题,主持
代表性论文:
1: Ding W, Qi M, Ma L, Xu X, Chen Y, Zhang W. ADP/ATP translocase 1 protects
against an α-synuclein-associated neuronal cell damage in Parkinson's disease
model. Cell Biosci. 2021 Jul 10;11(1):130.
2: Song J, Ding W, Liu Y, Lin L, Jia M, Liu S, Xue K. The mesenchymal property
of mouse mammary anlagen repopulating cell population is associated with its
stemness. Gene Expr Patterns. 2020 Dec;38:119151.
3: Chen Y, Xu Y, Yang S, Li S, Ding W, Zhang W. Deficiency of D-alanyl-D-alanine
ligase A attenuated cell division and greatly altered the proteome of
Mycobacterium smegmatis. Microbiologyopen. 2019 Sep;8(9):e00819.
4: Ding W, Zhang H, Xu Y, Ma L, Zhang W. Proteomic and Morphologic Evidence for
Taurine-5-Bromosalicylaldehyde Schiff Base as an Efficient Anti-Mycobacterial
Drug. J Microbiol Biotechnol. 2019 Aug 28;29(8):1221-1229.
5: Ma L, Song J, Sun X, Ding W, Fan K, Qi M, Xu Y, Zhang W. Role of microtubule-
associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's
disease. Aging (Albany NY). 2019 Jul 9;11(13):4597-4610.
6: Zhang W, Li S, Ma L, Ding W, Xu Y. Identification of a novel carboxypeptidase
encoded by Rv3627c that plays a potential role in mycobacteria morphology and
cell division. Enzyme Microb Technol. 2019 Jul;126:32-40.
7: Yang S, Xu Y, Wang Y, Ren F, Li S, Ding W, Ma Y, Zhang W. The Biological
Properties and Potential Interacting Proteins of d-Alanyl-d-alanine Ligase A
from Mycobacterium tuberculosis. Molecules. 2018 Feb 3;23(2):324.