个人简介
侯洁，博士，教授，硕士生导师，现任大连医科大学基础医学院副院长，生物制药教研室主任，生物制药专业负责人。
研究方向：
1.天然产物对微生物代谢功能调控的分子机制研究
2.生物发酵相关功能产品应用转化
代表性论文：
1. Fan Y, Wu Y, Hou J*，Wang P, Peng X*, Ge G*. Coumarin-based near-infrared fluorogenic probes: recent advances, challenges and future perspectives. Coordination chemistry reviews. 2023, 480：215020.
2.Chen X, Han Y, Chen L, Tian QL, Yin YL, Zhou Q, Zang SZ, Hou J*. Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases. Chem Biol Interact. 2022, 368:110222.
3.Chen L, Chen X, Bai Y, Zhao ZN, Cao YF, Liu LK, Jiang T, Hou J*. Inhibition of Escherichia coli nitroreductase by the constituents in Syzygium aromaticum. Chin J Nat Med. 2022;20(7): 506-517.
4.Bai Y, Chen L, Cao YF, Hou XD, Jia SN, Zhou Q, He YQ*, Hou J*. Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark. Planta Med, 2021, 87(8): 631-641.
5.Bai Y, Chen Lu, Wang PP, Tang YQ, Wu DC, Zhang CL, Zhou Q, Yan R*, Hou J*. Discovery of a naturally occurring broad-spectrum inhibitor against gut bacterial β-glucuronidases from Ginkgo biloba, Food & Function, 2021, 12(22): 11190-11201.
6.Hou XD#, Guan XQ#, Cao YF, Weng ZM, Hu Q, Liu HB, Jia SN, Zang SZ, Zhou Q, Yang L, Ge GB*, Hou J*. Inhibition of pancreatic lipase by the constituents in St. John's Wort: In vitro and in silico investigations. Int J Biol Macromol, 2020, 145: 620-633.
7.Hou XD#, Song LL#, Cao YF#, Wang YN, Zhou Q, Fang SQ, Wu DC, Zang SZ, Chen L, Bai Y, Ge GB*, Hou J*. Pancreatic lipase inhibitory constituents from Fructus Psoraleae. Chin J Nat Med, 2020, 18(5): 369-378.
8.Hou XD, Ge GB, Weng ZM, Dai ZR, Leng YH, Ding LL, Jin LL, Yu Y, Cao YF, Hou J*. Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors. Bioorganic chemistry, 2018, 80: 577-584.
9.Liu PK, Weng ZM, Ge GB, Li HL, Ding LL, Dai ZR, Hou XD, Leng YH, Yu Y, Hou J*. Biflavones from Ginkgo biloba as novel pancreatic lipase inhibitors: Inhibition potentials and mechanism. International Journal of Biological Macromolecules, 2018, 118: 2216-2223.
10.Weng ZM, Ge GB, Dou TY, Wang P, Liu PK, Tian XH, Qiao N, Yu Y, Zou LW, Zhou Q, Zhang WD, Hou J*. Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2. Bioorganic Chemistry, 2018, 77: 320-329.
11.Weng ZM, Wang P, Ge GB, Dai ZR, Wu DC, Zou LW, Dou TY, Zhang TY*, Yang L, Hou J*. Structure-activity relationships of flavonoids as natural inhibitors against E.coli β-glucuronidase, Food and Chemical Toxicology, 2017, 109: 975-983.
近年获奖情况及荣誉称号
1.侯洁，银杏双黄酮对脂肪酶的抑制作用及机制研究。辽宁省自然科学学术成果叁等奖（排名第一，2022年）
2.辽宁省优秀硕士毕业论文指导教师 （2019, 2020）
社会兼职
1.中国药理学分析药理学青年委员
2.大连医学会组织医学工程专科分会委员
3. Chin J Nat Med 青年编委
4. Chinese Medicine 青年编委
招生专业
生物学：生物技术
联系方式：houjie@dmu.edu.cn
